Veterinary Medicine – Society of Cannabis Clinicians https://www.cannabisclinicians.org Educating Healthcare Professionals about the Medical Use of Cannabis Mon, 20 Feb 2023 20:20:15 +0000 en-US hourly 1 https://wordpress.org/?v=6.2.3 https://www.cannabisclinicians.org/wp-content/uploads/2020/07/cropped-scc-flavicon-32x32.png Veterinary Medicine – Society of Cannabis Clinicians https://www.cannabisclinicians.org 32 32 Scientific Validation of Cannabidiol for Management of Dog and Cat Diseases https://www.cannabisclinicians.org/2023/02/18/scientific-validation-of-cannabidiol-for-management-of-dog-and-cat-diseases-2/ Sat, 18 Feb 2023 19:44:51 +0000 https://www.cannabisclinicians.org/?p=27777 Cannabidiol (CBD) is a non-psychotropic phytocannabinoid of the plant Cannabis sativa L. CBD is increasingly being explored as an alternative to conventional therapies to treat health disorders in dogs and cats. Mecha- nisms of action of CBD have been investigated mostly in rodents and in vitro and include modulation of CB1, CB2, 5-HT, GPR, and opioid receptors. In companion animals, CBD appears to have good bioavailability and safety profile with few side effects at physiological doses. Some dog studies have found CBD to improve clinical signs associated with osteoarthritis, pruritus, and epilepsy. However, further studies are needed to conclude a therapeu- tic action of CBD for each of these conditions, as well as for decreasing anxiety and aggression in dogs and cats. Herein, we summarize the avail- able scientific evidence associated with the mechanisms of action of CBD, including pharmacokinetics, safety, regulation, and efficacy in ameliorating various health conditions in dogs and cats.

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]]> Preoperative administration of cannabidiol (CBD) in healthy dogs undergoing elective surgery in Colombia: 16 Cases https://www.cannabisclinicians.org/2021/08/26/preoperative-administration-of-cannabidiol-cbd-in-healthy-dogs-undergoing-elective-surgery-in-colombia-16-cases/ Thu, 26 Aug 2021 16:41:32 +0000 https://www.cannabisclinicians.org/?p=24080 . The objective of this study is retrospectively review the effect of a single dose administration of two pharmaceutical grade CBD oils on basic cardiorespiratory parameters and anesthetic recovery of dogs undergoing elective surgery. Complete medical and anesthesia records of healthy dogs of the spay/neuter program of Corporaciòn Universitaria Santa Rosa de Cabal UNISARC whose owners approved a preoperative single dose of CBD were included for analysis. Dogs were considered clinically healthy based on physical examination, complete hemogram and serum creatinine and ALT concentration

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]]> Pharmacokinetics of Sativex® in Dogs: Towards a Potential Cannabinoid-Based Therapy for Canine Disorders https://www.cannabisclinicians.org/2020/07/17/pharmacokinetics-of-sativex-in-dogs-towards-a-potential-cannabinoid-based-therapy-for-canine-disorders/ Fri, 17 Jul 2020 22:31:40 +0000 https://www.cannabisclinicians.org/?p=18836 Authors: María Fernández-Trapero, Carmen Pérez-Díaz, Francisco Espejo-Porras, Eva de Lago, Javier Fernández-Ruiz Published in Biomolecules February 2020 Abstract The phytocannabinoid-based medicine Sativex® is currently marketed for the treatment of spasticity and...

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]]> Single-Dose Pharmacokinetics and Preliminary Safety Assessment with Use of CBD-Rich Hemp Nutraceutical in Healthy Dogs and Cats. https://www.cannabisclinicians.org/2019/10/19/single-dose-pharmacokinetics-and-preliminary-safety-assessment-with-use-of-cbd-rich-hemp-nutraceutical-in-healthy-dogs-and-cats/ Sat, 19 Oct 2019 14:33:30 +0000 http://www.cannabisclinicians.org/?p=16776 Authors: Kelly A. Deabold,Wayne S. Schwark,Lisa Wolf and Joseph J. Wakshlag Published in Animals 19 October 2019   Abstract The use of CBD-rich hemp products is becoming popular among pet...

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]]> Randomized blinded controlled clinical trial to assess the effect of oral cannabidiol administration in addition to conventional antiepileptic treatment on seizure frequency in dogs with intractable idiopathic epilepsy. https://www.cannabisclinicians.org/2019/06/01/randomized-blinded-controlled-clinical-trial-to-assess-the-effect-of-oral-cannabidiol-administration-in-addition-to-conventional-antiepileptic-treatment-on-seizure-frequency-in-dogs-with-intractable-i/ Sun, 02 Jun 2019 02:48:50 +0000 https://www.cannabisclinicians.org/?p=14512 Authors: Stephanie McGrath, Lisa R. Bartner, Sangeeta Rao, Rebecca A. Packer, Daniel L. Gustafson
Journal of the American Veterinary Medical Association, 1 June 2019
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OBJECTIVE: To assess the effect of oral cannabidiol (CBD) administration in addition to conventional antiepileptic treatment on seizure frequency in dogs with idiopathic epilepsy. DESIGN: Randomized blinded controlled clinical trial. ANIMALS: 26 client-owned dogs with intracta...

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]]> Species-specific susceptibility to cannabis-induced convulsions. https://www.cannabisclinicians.org/2019/05/01/species-specific-susceptibility-to-cannabis-induced-convulsions/ Wed, 01 May 2019 14:35:11 +0000 http://www.cannabisclinicians.org/?p=16779 Authors: Benjamin J. Whalley, Hong Lin, Lynne Bell, Thomas Hill, Amesha Patel, Roy A. Gray, C. Elizabeth Roberts, Orrin Devinsky, Michael Bazelot, Claire M. Williams, Gary J. Stephens Published in...

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]]> Localization of cannabinoid receptors CB1, CB2, GPR55, and PPARα in the canine gastrointestinal tract. https://www.cannabisclinicians.org/2018/08/01/localization-of-cannabinoid-receptors-cb1-cb2-gpr55-and-ppar%ce%b1-in-the-canine-gastrointestinal-tract/ Thu, 02 Aug 2018 01:07:31 +0000 https://www.cannabisclinicians.org/?p=14480 Authors: Giorgia Galiazzo, Fiorella Giancola, Agnese Stanzani, Federico Fracassi, Chiara Bernardini, Monica Forni, Marco Pietra, Roberto Chiocchetti
Histochemistry and Cell Biology, August 2018
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The endocannabinoid system (ECS) is composed of cannabinoid receptors, their endogenous ligands, and the enzymes involved in endocannabinoid turnover. Modulating the activity of the ECS may influence a variety of physiological and pathophysiological processes. A growing body o...

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]]> Marijuana intoxication in a cat. https://www.cannabisclinicians.org/2018/07/11/marijuana-intoxication-in-a-cat/ Thu, 12 Jul 2018 01:46:18 +0000 https://www.cannabisclinicians.org/?p=14493 Authors: Agnieszka Janeczek, Marcin Zawadzki, Pawel Szpot, Artur Niedzwiedz
Acta Veterinaria Scandinavica, 11 July 2018
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BACKGROUND: Cannabis from hemp (Cannabis sativa and C. indica) is one of the most common illegal drugs used by drug abusers. Indian cannabis contains around 70 alkaloids, and delta-9-tetrahydrocannabinol (delta-9-THC) is the most psychoactive substance. Animal intoxications oc...

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]]> Pharmacokinetics of cannabidiol administered by 3 delivery methods at 2 different dosages to healthy dogs. https://www.cannabisclinicians.org/2018/07/01/pharmacokinetics-of-cannabidiol-administered-by-3-delivery-methods-at-2-different-dosages-to-healthy-dogs/ Sun, 01 Jul 2018 17:45:32 +0000 https://www.cannabisclinicians.org/?p=14385 Authors: Lisa R. Bartner, Stephanie McGrath, Sangeeta Rao, Linda K. Hyatt, Luke A. Wittenburg
Canadian Journal of Veterinary Research, July 2018
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The purpose of this study was to determine the pharmacokinetics of cannabidiol (CBD) in healthy dogs. Thirty, healthy research dogs were assigned to receive 1 of 3 formulations (oral microencapsulated oil beads, oral CBD-infused oil, or CBD-infused transdermal cream), at a dos...

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]]> Pharmacokinetics, Safety, and Clinical Efficacy of Cannabidiol Treatment in Osteoarthritic Dogs. https://www.cannabisclinicians.org/2018/07/01/pharmacokinetics-safety-and-clinical-efficacy-of-cannabidiol-treatment-in-osteoarthritic-dogs/ Sun, 01 Jul 2018 17:39:19 +0000 https://www.cannabisclinicians.org/?p=14383 Authors: Lauri-Jo Gamble1, Jordyn M. Boesch, Christopher W. Frye, Wayne S. Schwark, Sabine Mann, Lisa Wolfe, Holly Brown, Erin S. Berthelsen, Joseph J. Wakshlag
Frontiers in Veterinary Science, July 2018
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Objectives: The objectives of this study were to determine basic oral pharmacokinetics, and assess safety and analgesic efficacy of a cannabidiol (CBD) based oil in dogs with osteoarthritis (OA). Methods: Single-dose pharmacokinetics was performed using two different doses of...

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