Obesity – Society of Cannabis Clinicians https://www.cannabisclinicians.org Educating Healthcare Professionals about the Medical Use of Cannabis Thu, 29 Dec 2022 22:04:24 +0000 en-US hourly 1 https://wordpress.org/?v=6.2.3 https://www.cannabisclinicians.org/wp-content/uploads/2020/07/cropped-scc-flavicon-32x32.png Obesity – Society of Cannabis Clinicians https://www.cannabisclinicians.org 32 32 Mutual Links between the Endocannabinoidome and the Gut Microbiome, with Special Reference to Companion Animals: A Nutritional Viewpoint https://www.cannabisclinicians.org/2022/12/29/mutual-links-between-the-endocannabinoidome-and-the-gut-microbiome-with-special-reference-to-companion-animals-a-nutritional-viewpoint/ Thu, 29 Dec 2022 22:04:24 +0000 https://www.cannabisclinicians.org/?p=27389 Dysbiosis, which is an imbalance of gut microbial composition and function, can be caused by several external as well as internal factors, contributing to the onset of human and animal disorders, not limited to the gastrointestinal tract. Accordingly, the mechanisms leading to disease development involve a crucial interaction between the gut microbiota, their metabolic products, and the host. The expanded endocannabinoid system, also known as the “endocannabinoidome”, includes endocannabinoids (e.g., anandamide) and endocannabinoid-like mediators (e.g., palmitoylethanolamide), their receptors and metabolic enzymes. Dysregulation of this newly recognized endogenous system is also involved in several diseases. It is becoming increasingly apparent that a link between the endocannabinoidome and the gut microbiome exists. Here, we review some of the latest discoveries related to the functional link between these two complex systems and the disorders emerging from the malfunctioning of such a mutual interaction: for example, idiopathic inflammation, chronic enteropathies, metabolic disease and certain neuroinflammatory disorders. It is expected that in the near future new nutritional tools will emerge based on the expanding knowledge in this cutting-edge field.

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]]> Phytocannabinoids: Useful Drugs for the Treatment of Obesity? Special Focus on Cannabidiol. https://www.cannabisclinicians.org/2020/03/04/phytocannabinoids-useful-drugs-for-the-treatment-of-obesity-special-focus-on-cannabidiol/ Wed, 04 Mar 2020 13:44:22 +0000 https://www.cannabisclinicians.org/?p=17324 Authors: Patrycja Bielawie, Ewa Harasim-Symbor, Adrian Chabowski
Frontiers in Endocrinology, 4 March 2020
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Currently, an increasing number of diseases related to insulin resistance and obesity is an alarming problem worldwide. It is well-known that the above states can lead to the development of type 2 diabetes, hypertension, and cardiovascular diseases. An excessive amount of tria...

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]]> Cannabis: From a Plant That Modulates Feeding Behaviors toward Developing Selective Inhibitors of the Peripheral Endocannabinoid System for the Treatment of Obesity and Metabolic Syndrome. https://www.cannabisclinicians.org/2019/05/15/cannabis-from-a-plant-that-modulates-feeding-behaviors-toward-developing-selective-inhibitors-of-the-peripheral-endocannabinoid-system-for-the-treatment-of-obesity-and-metabolic-syndrome/ Wed, 15 May 2019 20:53:59 +0000 https://www.cannabisclinicians.org/?p=17241 Authors: Shira Hirsch, Joseph Tam
Toxins, 15 May 2019
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In this review, we discuss the role of the endocannabinoid (eCB) system in regulating energy and metabolic homeostasis. Endocannabinoids, via activating the cannabinoid type-1 receptor (CB1R), are commonly known as mediators of the thrifty phenotype hypothesis due to their act...

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]]> Role of Cannabinoid Receptor Type 1 in Insulin Resistance and Its Biological Implications. https://www.cannabisclinicians.org/2019/04/29/role-of-cannabinoid-receptor-type-1-in-insulin-resistance-and-its-biological-implications/ Mon, 29 Apr 2019 20:58:55 +0000 https://www.cannabisclinicians.org/?p=17244 Authors: Arulkumar Nagappan, Jooyeon Shin, Myeong Ho Jung
International Journal of Molecular Sciences, 29 April 2019
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Endogenous cannabinoids (ECs) are lipid-signaling molecules that specifically bind to cannabinoid receptor types 1 and 2 (CB1R and CB2R) and are highly expressed in central and many peripheral tissues under pathological conditions. Activation of hepatic CB1R is associated with...

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]]> Intestinal permeability–a new target for disease prevention and therapy. https://www.cannabisclinicians.org/2014/11/18/intestinal-permeability-a-new-target-for-disease-prevention-and-therapy/ Tue, 18 Nov 2014 18:07:56 +0000 https://www.cannabisclinicians.org/?p=17185 Authors: Stephan C. Bischoff, Giovanni Barbara, Wim Buurman, Theo Ockhuizen, Jörg-Dieter Schulzke, et al
BMC Gastroenterology, 18 November 2014
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Data are accumulating that emphasize the important role of the intestinal barrier and intestinal permeability for health and disease. However, these terms are poorly defined, their assessment is a matter of debate, and their clinical significance is not clearly established. In...

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]]> The emerging role of the endocannabinoid system in cardiovascular disease. https://www.cannabisclinicians.org/2009/06/01/the-emerging-role-of-the-endocannabinoid-system-in-cardiovascular-disease/ Mon, 01 Jun 2009 17:40:22 +0000 https://www.cannabisclinicians.org/?p=14955 Authors: Pál Pacher, Sabine Steffens
Seminars in Immunopathology, June 2009
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Endocannabinoids are endogenous bioactive lipid mediators present both in the brain and various peripheral tissues, which exert their biological effects via interaction with specific G-protein-coupled cannabinoid receptors, the CB(1) and CB(2). Pathological overactivation of t...

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