Mitochondrial disease – Society of Cannabis Clinicians https://www.cannabisclinicians.org Educating Healthcare Professionals about the Medical Use of Cannabis Thu, 29 Dec 2022 22:04:24 +0000 en-US hourly 1 https://wordpress.org/?v=6.2.3 https://www.cannabisclinicians.org/wp-content/uploads/2020/07/cropped-scc-flavicon-32x32.png Mitochondrial disease – Society of Cannabis Clinicians https://www.cannabisclinicians.org 32 32 Mutual Links between the Endocannabinoidome and the Gut Microbiome, with Special Reference to Companion Animals: A Nutritional Viewpoint https://www.cannabisclinicians.org/2022/12/29/mutual-links-between-the-endocannabinoidome-and-the-gut-microbiome-with-special-reference-to-companion-animals-a-nutritional-viewpoint/ Thu, 29 Dec 2022 22:04:24 +0000 https://www.cannabisclinicians.org/?p=27389 Dysbiosis, which is an imbalance of gut microbial composition and function, can be caused by several external as well as internal factors, contributing to the onset of human and animal disorders, not limited to the gastrointestinal tract. Accordingly, the mechanisms leading to disease development involve a crucial interaction between the gut microbiota, their metabolic products, and the host. The expanded endocannabinoid system, also known as the “endocannabinoidome”, includes endocannabinoids (e.g., anandamide) and endocannabinoid-like mediators (e.g., palmitoylethanolamide), their receptors and metabolic enzymes. Dysregulation of this newly recognized endogenous system is also involved in several diseases. It is becoming increasingly apparent that a link between the endocannabinoidome and the gut microbiome exists. Here, we review some of the latest discoveries related to the functional link between these two complex systems and the disorders emerging from the malfunctioning of such a mutual interaction: for example, idiopathic inflammation, chronic enteropathies, metabolic disease and certain neuroinflammatory disorders. It is expected that in the near future new nutritional tools will emerge based on the expanding knowledge in this cutting-edge field.

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]]> Cannabinoids for treatment of Alzheimer’s disease: moving toward the clinic. https://www.cannabisclinicians.org/2014/03/05/cannabinoids-for-treatment-of-alzheimers-disease-moving-toward-the-clinic/ Thu, 06 Mar 2014 01:21:38 +0000 http://www.cannabisclinicians.org/?p=13362 Authors: Ester Aso, Isidre Ferrer
Frontiers in Pharmacology, 5 March 2014
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The limited effectiveness of current therapies against Alzheimer's disease (AD) highlights the need for intensifying research efforts devoted to developing new agents for preventing or retarding the disease process. During the last few years, targeting the endogenous cannabino...

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]]> The endocannabinoid system in normal and pathological brain ageing. https://www.cannabisclinicians.org/2012/12/05/the-endocannabinoid-system-and-brain-aging/ Wed, 05 Dec 2012 21:36:10 +0000 http://cannabisclinicians.org/?p=6468 Authors: Andras Bilkei-Gorzo
Philosophical Transactions of the Royal Society B: Biological Sciences, 5 December 2012
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The role of endocannabinoids as inhibitory retrograde transmitters is now widely known and intensively studied. However, endocannabinoids also influence neuronal activity by exerting neuroprotective effects and regulating glial responses. This review centres around this less-s...

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