General wellness – Society of Cannabis Clinicians https://www.cannabisclinicians.org Educating Healthcare Professionals about the Medical Use of Cannabis Mon, 09 Oct 2023 16:08:41 +0000 en-US hourly 1 https://wordpress.org/?v=6.2.3 https://www.cannabisclinicians.org/wp-content/uploads/2020/07/cropped-scc-flavicon-32x32.png General wellness – Society of Cannabis Clinicians https://www.cannabisclinicians.org 32 32 Cannabidiol attenuates inflammatory impairment of intestinal cells expanding biomaterial-based therapeutic approaches https://www.cannabisclinicians.org/2023/10/09/cannabidiol-attenuates-inflammatory-impairment-of-intestinal-cells-expanding-biomaterial-based-therapeutic-approaches/ Mon, 09 Oct 2023 16:08:11 +0000 https://www.cannabisclinicians.org/?p=29389 Cannabis-based biomaterials have the potential to deliver anti-inflammatory therapeutics specifically to desired cells, tissues, and organs, enhancing drug delivery and the effectiveness of anti-inflammatory treatment while minimizing toxicity. As a major component of Cannabis, Cannabidiol (CBD) has gained major attention in recent years because of its potential therapeutic properties, e.g., for restoring a disturbed barrier resulting from inflammatory conditions. The aim of this study was to test the hypothesis that CBD has beneficial effects under normal and inflammatory conditions in the established non-transformed intestinal epithelial cell model IPEC-J2.

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]]> Modulation of pulmonary immune function by inhaled cannabis products and consequences for lung disease https://www.cannabisclinicians.org/2023/04/02/modulation-of-pulmonary-immune-function-by-inhaled-cannabis-products-and-consequences-for-lung-disease/ Sun, 02 Apr 2023 13:07:26 +0000 https://www.cannabisclinicians.org/?p=28282 The lungs, in addition to participating in gas exchange, represent the first line of defense against inhaled pathogens and respiratory toxicants. Cells lining the airways and alveoli include epithelial cells and alveolar macrophages, the latter being resident innate immune cells important in surfactant recycling, protection against bacterial invasion and modulation of lung immune homeostasis. Environmental exposure to toxicants found in cigarette smoke, air pollution and cannabis can alter the number and function of immune cells in the lungs. Cannabis (marijuana) is a plant-derived product that is typically inhaled in the form of smoke from a joint. However, alternative delivery methods such as vaping, which heats the plant without combustion, are becoming more common. Cannabis use has increased in recent years, coinciding with more countries legalizing cannabis for both recreational and medicinal purposes. Cannabis may have numerous health benefits owing to the presence of cannabinoids that dampen immune function and therefore tame inflammation that is associated with chronic diseases such as arthritis.

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]]> A Retrospective Medical Record Review of Adults with Non-Cancer Diagnoses Prescribed Medicinal Cannabis https://www.cannabisclinicians.org/2023/03/18/a-retrospective-medical-record-review-of-adults-with-non-cancer-diagnoses-prescribed-medicinal-cannabis-2/ Sat, 18 Mar 2023 14:00:49 +0000 https://www.cannabisclinicians.org/?p=28089 Research describing patients using medicinal cannabis and its effectiveness is lacking. We aimed to describe adults with non-cancer diagnoses who are prescribed medicinal cannabis via a retrospective medical record review and assess its effectiveness and safety. From 157 Australian records, most were female (63.7%; mean age 63.0 years). Most patients had neurological (58.0%) or musculoskeletal (24.8%) conditions. Medicinal cannabis was perceived beneficial by 53.5% of patients.

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]]> The Endocannabinoid System and Physical Exercise https://www.cannabisclinicians.org/2023/02/10/the-endocannabinoid-system-and-physical-exercise/ Sat, 11 Feb 2023 02:32:19 +0000 https://www.cannabisclinicians.org/?p=27728 The endocannabinoid system (ECS) is involved in various processes, including brain plas- ticity, learning and memory, neuronal development, nociception, inflammation, appetite regulation, digestion, metabolism, energy balance, motility, and regulation of stress and emotions. Physical exercise (PE) is considered a valuable non-pharmacological therapy that is an immediately available and cost-effective method with a lot of health benefits, one of them being the activation of the endoge- nous cannabinoids. Endocannabinoids (eCBs) are generated as a response to high-intensity activities and can act as short-term circuit breakers, generating antinociceptive responses for a short and variable period of time. A runner’s high is an ephemeral feeling some sport practitioners experience during endurance activities, such as running. The release of eCBs during sustained physical exercise appears to be involved in triggering this phenomenon. The last decades have been characterized by an increased interest in this emotional state induced by exercise, as it is believed to alleviate pain, induce mild sedation, increase euphoric levels, and have anxiolytic effects. This review provides information about the current state of knowledge about endocannabinoids and physical effort and also an overview of the studies published in the specialized literature about this subject.

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]]> Cannabidiol in Dentistry: A Scoping Review https://www.cannabisclinicians.org/2022/10/29/cannabidiol-in-dentistry-a-scoping-review/ Sat, 29 Oct 2022 18:06:21 +0000 https://www.cannabisclinicians.org/?p=27037 Cannabidiol (CBD) has been gaining increased attention in contemporary society but seems to have been little explored in dentistry. This scoping review mapped the scientific and technological scenarios related to the use of CBD in dentistry. Peer-reviewed publications were searched in five international databases, patents were searched in five technological platforms. In total, 11 articles and 13 patents involving CBD in dentistry-related applications were included. The countries contributing to most articles were Brazil (27.3%) and USA (18.2%). The studies involved experiments on animals (63.6%) and/or using bacteria or cells (36.4%), and no clinical study was found.

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]]> Residues of herbal hemp leaf teas – How much of the cannabinoids remain? https://www.cannabisclinicians.org/2021/04/19/residues-of-herbal-hemp-leaf-teas-how-much-of-the-cannabinoids-remain/ Mon, 19 Apr 2021 17:24:04 +0000 https://www.cannabisclinicians.org/?p=22562 Herbal teas of fiber-type hemp varieties (Cannabis sativa L.) rich in cannabidiolic acid (CBDA) and cannabidiol (CBD) and poor in Δ9-tetrahydrocannabinol acid (THCA) and Δ9-tetrahydrocannabinol (THC) are very popular today. The conditions for preparing herbal infusions are not well standardized and analysis of the lipophilic cannabinoids in infusions is difficult. Therefore, we analyzed the hemp leaf residues after tea preparation by using a response surface modelling approach to estimate the effects of variations in temperature, water volume and extraction time on the residual content of five cannabinoids (CBDA, CBD, THCA, THC, cannabinol (CBN)) in the hemp leaves after extraction.

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]]> Cannabidiol Inhibits SARS-CoV-2 Replication and Promotes the Host Innate Immune Response https://www.cannabisclinicians.org/2021/03/29/cannabidiol-inhibits-sars-cov-2-replication-and-promotes-the-host-innate-immune-response/ Mon, 29 Mar 2021 15:46:51 +0000 https://www.cannabisclinicians.org/?p=22301 The rapid spread of COVID-19 underscores the need for new treatments. Here we report that cannabidiol (CBD), a compound produced by the cannabis plant, inhibits SARS-CoV-2 infection. CBD and its metabolite, 7-OH-CBD, but not congeneric cannabinoids, potently block SARS-CoV-2 replication in lung epithelial cells. CBD acts after cellular infection, inhibiting viral gene expression and reversing many effects of SARS-CoV-2 on host gene transcription. CBD induces interferon expression and up-regulates its antiviral signaling pathway.

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]]> The Case for Cannabis: Cannabis, Testosterone, and Gender Inequality https://www.cannabisclinicians.org/2021/02/15/the-case-for-cannabiscannabis-testosterone-and-gender-inequality/ Mon, 15 Feb 2021 18:48:32 +0000 https://www.cannabisclinicians.org/?p=21683 Some men worry that they are not manly enough, and wonder if a lack of testosterone is the reason. Others comment, like a reader recently did, on the age-old fearmongering, unscientific propaganda about Cannabis (specifically THC) that it is a “potent suppressor of testosterone.”

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]]> Effect of cannabis on oxaliplatin-induced peripheral neuropathy among oncology patients: a retrospective analysis https://www.cannabisclinicians.org/2021/02/15/effect-of-cannabis-on-oxaliplatin-induced-peripheral-neuropathy-among-oncology-patients-a-retrospective-analysis/ Mon, 15 Feb 2021 16:26:50 +0000 https://www.cannabisclinicians.org/?p=21688 Chemotherapy-induced peripheral neuropathy (CIPN) is a common and dosage-limited oxaliplatin-related toxicity. To date, there are no successful interventions for CIPN prevention or treatment.

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]]> Effects of cannabis use on alcohol consumption in a sample of treatment-engaged heavy drinkers in Colorado https://www.cannabisclinicians.org/2021/02/08/effects-of-cannabis-use-on-alcohol-consumption-in-a-sample-of-treatment-engaged-heavy-drinkers-in-colorado/ Mon, 08 Feb 2021 15:52:03 +0000 https://www.cannabisclinicians.org/?p=21536 Cannabis is commonly used among people who drink alcohol, but evidence suggests a nuanced relationship between alcohol consumption and cannabis use. In particular, among individuals undergoing alcohol treatment the impact of cannabis on alcohol intake may depend upon cannabis use frequency.

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