Depression – Society of Cannabis Clinicians https://www.cannabisclinicians.org Educating Healthcare Professionals about the Medical Use of Cannabis Sat, 26 Aug 2023 16:20:25 +0000 en-US hourly 1 https://wordpress.org/?v=6.2.3 https://www.cannabisclinicians.org/wp-content/uploads/2020/07/cropped-scc-flavicon-32x32.png Depression – Society of Cannabis Clinicians https://www.cannabisclinicians.org 32 32 Self-Reported Effects of Medical Cannabis on Illness Severity, Depression and Anxiety in Fibromyalgia Patients: A Large Retrospective Case Series https://www.cannabisclinicians.org/2023/08/26/self-reported-effects-of-medical-cannabis-on-illness-severity-depression-and-anxiety-in-fibromyalgia-patients-a-large-retrospective-case-series/ Sat, 26 Aug 2023 16:18:08 +0000 https://www.cannabisclinicians.org/?p=29123 To observe the effect of cannabis on fibromyalgia illness severity and related symptoms of depression and anxiety. A retrospective chart review was conducted to identify all patients who indicated fibromyalgia as a primary reason for seeking medical cannabis and completed at least 1 follow-up visit at Harvest Medicine clinics from January 2017 to July 2021. Data extracted from patient charts included Patient Health Questionnaire-9 (PHQ-9) scores, Generalized Anxiety Disorder-7 (GAD-7) scores, and self-reported illness severity scores. Changes in these scores between a patient’s intake and first follow-up visits were calculated and analyzed for significance overall and in different demographic subgroups. Patients for whom no follow-up data were available were excluded.

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]]> Assessment of clinical outcomes of medicinal cannabis therapy for depression: analysis from the UK Medical Cannabis Registry https://www.cannabisclinicians.org/2023/01/06/assessment-of-clinical-outcomes-of-medicinal-cannabis-therapy-for-depression-analysis-from-the-uk-medical-cannabis-registry/ Fri, 06 Jan 2023 23:02:17 +0000 https://www.cannabisclinicians.org/?p=27436 Although pre-clinical experiments associate cannabinoids with reduced depressive symptoms, there is a paucity of clinical evidence. This study aims to analyze the health-related quality of life changes and safety outcomes in patients prescribed cannabis-based medicinal products (CBMPs) for depression.

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]]> Rapid treatments for depression: Endocannabinoid system as a therapeutic target https://www.cannabisclinicians.org/2022/08/11/rapid-treatments-for-depression-endocannabinoid-system-as-a-therapeutic-target/ Thu, 11 Aug 2022 14:15:56 +0000 https://www.cannabisclinicians.org/?p=26656 Current first-line treatments for major depressive disorder (MDD), i.e., antidepressant drugs and psychotherapy, show delayed onset of therapeutic effect as late as 2–3 weeks or more. In the clinic, the speed of beginning of the actions of antidepressant drugs or other interventions is vital for many reasons.

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]]> An investigation of cannabis use for insomnia in depression and anxiety in a naturalistic sample https://www.cannabisclinicians.org/2022/08/11/an-investigation-of-cannabis-use-for-insomnia-in-depression-and-anxiety-in-a-naturalistic-sample/ Thu, 11 Aug 2022 13:53:52 +0000 https://www.cannabisclinicians.org/?p=26644 Little is known about cannabis use for insomnia in individuals with depression, anxiety, and comorbid depression and anxiety. To develop a better understanding of distinct profiles of cannabis use for insomnia management, a retrospective cohort study was conducted on a large naturalistic sample.

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]]> Reviewing the Role of the Endocannabinoid System in the Pathophysiology of Depression https://www.cannabisclinicians.org/2022/03/14/reviewing-the-role-of-the-endocannabinoid-system-in-the-pathophysiology-of-depression/ Mon, 14 Mar 2022 22:40:08 +0000 https://www.cannabisclinicians.org/?p=26271 Major depressive disorder is a high-impact, debilitating disease and it is currently considered the most prevalent mental illness. It is associated with disability, as well as increased morbidity and mortality. Despite its significant repercussions in our society, its exact pathophysiology remains unclear and therefore, available antidepressant treatment options are limited and, in some cases, ineffective. In the past years, research has focused on the development of a multifactorial theory of depression. Simultaneously, evidence supporting the role of the endocannabinoid system in the neurobiology of neuropsychiatric diseases has emerged. Studies have shown that the endocannabinoid system strongly impacts neurotransmission, and the neuroendocrine and neuroimmune systems, which are known to be dysfunctional in depressive patients. Accordingly, common antidepressants were shown to have a direct impact on the expression of cannabinoid receptors throughout the brain. Therefore, the relationship between the endocannabinoid system and major depressive disorder is worth consideration. Nevertheless, most studies focus on smaller pieces of what is undoubtedly a larger mosaic of interdependent processes. Therefore, the present review summarizes the existing literature regarding the role of the endocannabinoid system in depression aiming to integrate this information into a holistic picture for a better understanding of the relationship between the two.

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]]> FURTHER EVIDENCE OF ANXIETY- AND DEPRESSION-LIKE BEHAVIOR FOR TOTAL GENETIC ABLATION OF CANNABINOID RECEPTOR TYPE 1 https://www.cannabisclinicians.org/2020/11/16/further-evidence-of-anxiety-and-depression-like-behavior-for-total-genetic-ablation-of-cannabinoid-receptor-type-1/ Mon, 16 Nov 2020 16:05:00 +0000 https://www.cannabisclinicians.org/?p=20587 Authors: Delia Soriano, Alicia Brusco, Laura Caltana Published in Behavioural Brain Research November 2020 Abstract Cannabinoid receptor type 1 (CB1R) is the most abundant cannabinoid receptor in central nervous system....

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]]> Possible therapeutic applications of cannabis in the neuropsychopharmacology field. https://www.cannabisclinicians.org/2020/02/10/possible-therapeutic-applications-of-cannabis-in-the-neuropsychopharmacology-field/ Mon, 10 Feb 2020 16:49:25 +0000 https://www.cannabisclinicians.org/?p=17349 Authors: Javier Fernández-Ruiz, Ismael Galve-Roperh, Onintza Sagredo, Manuel Guzmán
European Neuropsychopharmacology, 10 February 2020
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Cannabis use induces a plethora of actions on the CNS via its active chemical ingredients, the so-called phytocannabinoids. These compounds have been frequently associated with the intoxicating properties of cannabis preparations. However, not all phytocannabinoids are psychot...

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]]> Cannabinoids in depressive disorders. https://www.cannabisclinicians.org/2018/11/15/cannabinoids-in-depressive-disorders/ Thu, 15 Nov 2018 18:57:59 +0000 https://www.cannabisclinicians.org/?p=17196 Authors: Ewa Poleszak, Sylwia Wośko, Karolina Sławińska, Aleksandra Szopa, Andrzej Wróbel, Anna Serefko
Life Sciences, 15 November 2018
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Cannabis sativa is one of the most popular recreational and medicinal plants. Benefits from use of cannabinoid agents in epilepsy, multiple sclerosis, Parkinson's disease, Alzheimer's disease, and others have been suggested. It seems that the endocannabinoid system is also inv...

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]]> Marijuana use during and after pregnancy and association of prenatal use on birth outcomes: A population-based study. https://www.cannabisclinicians.org/2018/06/01/marijuana-use-during-and-after-pregnancy-and-association-of-prenatal-use-on-birth-outcomes-a-population-based-study/ Fri, 01 Jun 2018 18:14:47 +0000 https://www.cannabisclinicians.org/?p=15545 Authors: Jean Y. Ko, Van T. Tong, Jennifer M. Bombard, Donald K. Hayes, John Davy, et al
Drug and Alcohol Dependence, June 2018
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BACKGROUND: We sought to describe the correlates of marijuana use during and after pregnancy, and to examine the independent relationship between prenatal marijuana use and infant outcomes. STUDY DESIGN: We used state-specific data from the Pregnancy Risk Assessment Monitoring...

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]]> Effects of Marijuana on Mental Health: Depression. https://www.cannabisclinicians.org/2017/06/01/effects-of-marijuana-on-mental-health-depression/ Thu, 01 Jun 2017 18:12:09 +0000 https://www.cannabisclinicians.org/?p=17199 Authors: Susan A. Stoner
Alcohol & Drug Abuse Institute, University of Washington, June 2017
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THC and CBD appear to have antidepressant-like effects in animal models at certain doses but not others. Marijuana has been associated with diminished motivation, but a distinct “cannabis amotivational syndrome” has yet to be substantiated. Studies looking at whether marijuana...

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