Phenotype – Society of Cannabis Clinicians https://www.cannabisclinicians.org Educating Healthcare Professionals about the Medical Use of Cannabis Tue, 28 Jun 2022 04:34:11 +0000 en-US hourly 1 https://wordpress.org/?v=6.2.3 https://www.cannabisclinicians.org/wp-content/uploads/2020/07/cropped-scc-flavicon-32x32.png Phenotype – Society of Cannabis Clinicians https://www.cannabisclinicians.org 32 32 The phytochemical diversity of commercial Cannabis in the United States https://www.cannabisclinicians.org/2022/06/06/the-phytochemical-diversity-of-commercial-cannabis-in-the-united-states/ Mon, 06 Jun 2022 22:51:37 +0000 https://www.cannabisclinicians.org/?p=26488 The legal status of Cannabis is changing, fueling an increasing diversity of Cannabis-derived products. Because Cannabis contains dozens of chemical compounds with potential psychoactive or medicinal effects, understanding this phytochemical diversity is crucial. The legal Cannabis industry heavily markets products to consumers based on widely used labeling systems purported to predict the effects of different “strains.” We analyzed the cannabinoid and terpene content of commercial Cannabis samples across six US states, finding distinct chemical phenotypes (chemotypes) which are reliably present. By comparing the observed phytochemical diversity to the commercial labels commonly attached to Cannabis-derived product samples, we show that commercial labels do not consistently align with the observed chemical diversity. However, certain labels do show a biased association with specific chemotypes. These results have implications for the classification of commercial Cannabis, design of animal and human research, and regulation of consumer marketing—areas which today are often divorced from the chemical reality of the Cannabis-derived material they wish to represent.

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The effects of cannabinoids on the pharmacokinetics of indinavir and nelfinavir https://www.cannabisclinicians.org/2021/06/17/the-effects-of-cannabinoids-on-the-pharmacokinetics-of-indinavir-and-nelfinavir/ Thu, 17 Jun 2021 19:39:43 +0000 https://www.cannabisclinicians.org/?p=23353 Cannabinoids, including smoked marijuana and delta9-tetrahydrocannabinol (THC) (dronabinol, Marinol), have been used to treat human immunodeficiency virus-1 (HIV)-associated anorexia and weight loss. Concerns have been raised, however, that these compounds might have adverse effects on the immune system of subjects with HIV infection.

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Short-term effects of cannabinoids on immune phenotype and function in HIV-1-infected patients https://www.cannabisclinicians.org/2021/06/17/short-term-effects-of-cannabinoids-on-immune-phenotype-and-function-in-hiv-1-infected-patients/ Thu, 17 Jun 2021 19:32:22 +0000 https://www.cannabisclinicians.org/?p=23349 Cannabinoids, including smoked marijuana and delta9-tetrahydrocannabinol (THC) (dronabinol, Marinol), have been used to treat human immunodeficiency virus-1 (HIV)-associated anorexia and weight loss. Concerns have been raised, however, that these compounds might have adverse effects on the immune system of subjects with HIV infection.

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