Nicotine – Society of Cannabis Clinicians https://www.cannabisclinicians.org Educating Healthcare Professionals about the Medical Use of Cannabis Sat, 29 Apr 2023 12:04:40 +0000 en-US hourly 1 https://wordpress.org/?v=6.2.3 https://www.cannabisclinicians.org/wp-content/uploads/2020/07/cropped-scc-flavicon-32x32.png Nicotine – Society of Cannabis Clinicians https://www.cannabisclinicians.org 32 32 Inhibition of Nicotine Metabolism by Cannabidiol (CBD) and 7-Hydroxycannabidiol (7-OH-CBD) https://www.cannabisclinicians.org/2023/04/29/inhibition-of-nicotine-metabolism-by-cannabidiol-cbd-and-7-hydroxycannabidiol-7-oh-cbd/ Sat, 29 Apr 2023 12:04:40 +0000 https://www.cannabisclinicians.org/?p=28485 Cannabis-based products have experienced notable increases in co-usage alongside tobacco products. Several cannabinoids exhibit inhibition of a number of cytochrome P450 (CYP) and UDP glucuronosyltransferase (UGT) enzymes, but few studies have examined their inhibition of enzymes involved in nicotine metabolism. The goal of the present study was to examine potential drug–drug interactions occurring in the nicotine metabolism pathway perpetrated by cannabidiol (CBD) and its active metabolite, 7-hydroxy-CBD (7-OH-CBD). The inhibitory effects of CBD and 7-OH-CBD were tested in microsomes from HEK293 cells overexpressing individual metabolizing enzymes and from human liver tissue. Assays with overexpressing microsomes demonstrated that CBD and 7-OH-CBD inhibited CYP-mediated nicotine metabolism.

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]]> Healthcare provider and medical cannabis patient communication regarding referral and medication substitution: the Canadian context https://www.cannabisclinicians.org/2022/07/07/healthcare-provider-and-medical-cannabis-patient-communication-regarding-referral-and-medication-substitution-the-canadian-context/ Thu, 07 Jul 2022 18:16:38 +0000 https://www.cannabisclinicians.org/?p=26531 Patients use medical cannabis for a wide array of illnesses and symptoms, and many substitute canna- bis for pharmaceuticals. This substitution often occurs without physician oversight, raising patient safety concerns. We aimed to characterize substitution and doctor-patient communication patterns in Canada, where there is a mature market and national regulatory system for medical cannabis.
Methods: We conducted an anonymous, cross-se

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]]> A Scoping Review of the Use of Cannabis and Its Extracts as Potential Harm Reduction Strategies: Insights from Preclinical and Clinical Research https://www.cannabisclinicians.org/2020/07/17/a-scoping-review-of-the-use-of-cannabis-and-its-extracts-as-potential-harm-reduction-strategies-insights-from-preclinical-and-clinical-research/ Fri, 17 Jul 2020 22:46:27 +0000 https://www.cannabisclinicians.org/?p=18841 Authors: James Siklos-Whillans, Alia Bacchus, Laurie A. Manwell Published in International Journal of Mental Health and Addiction March 2020 Abstract Cannabis as a harm reduction strategy (HRS) is supported by evidence...

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