Terpenes – Society of Cannabis Clinicians https://www.cannabisclinicians.org Educating Healthcare Professionals about the Medical Use of Cannabis Sat, 06 May 2023 00:54:13 +0000 en-US hourly 1 https://wordpress.org/?v=6.2.3 https://www.cannabisclinicians.org/wp-content/uploads/2020/07/cropped-scc-flavicon-32x32.png Terpenes – Society of Cannabis Clinicians https://www.cannabisclinicians.org 32 32 Antitumor Effects of Cannabis sativa Bioactive Compounds on Colorectal Carcinogenesis https://www.cannabisclinicians.org/2023/05/05/antitumor-effects-of-cannabis-sativa-bioactive-compounds-on-colorectal-carcinogenesis/ Sat, 06 May 2023 00:54:13 +0000 https://www.cannabisclinicians.org/?p=28518 Cannabis sativa is a multipurpose plant that has been used in medicine for centuries. Recently, considerable research has focused on the bioactive compounds of this plant, particularly cannabinoids and terpenes. Among other properties, these compounds exhibit antitumor effects in several cancer types, including colorectal cancer (CRC). Cannabinoids show positive effects in the treatment of CRC by inducing apoptosis, proliferation, metastasis, inflammation, angiogenesis, oxidative stress, and autophagy. Terpenes, such as β-caryophyllene, limonene, and myrcene, have also been reported to have potential antitumor effects on CRC through the induction of apoptosis, the inhibition of cell proliferation, and angiogenesis. In addition, synergy effects between cannabinoids and terpenes are believed to be important factors in the treatment of CRC. This review focuses on the current knowledge about the potential of cannabinoids and terpenoids from C. sativa to serve as bioactive agents for the treatment of CRC while evidencing the need for further research to fully elucidate the mechanisms of action and the safety of these compounds.

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]]> SELECTED CANNABIS TERPENES SYNERGIZE WITH THC TO PRODUCE INCREASED CB1 RECEPTOR ACTIVATION https://www.cannabisclinicians.org/2023/04/22/selected-cannabis-terpenes-synergize-with-thc-to-produce-increased-cb1-receptor-activation/ Sat, 22 Apr 2023 18:15:19 +0000 https://www.cannabisclinicians.org/?p=28424 The cannabis plant exerts its pharmaceutical activity primarily by the binding of cannabinoids to two G protein-coupled cannabinoid receptors, CB1 and CB2. The role that cannabis terpenes play in this activation has been considered and debated repeatedly, based on only limited experimental results. In the current study we used a controlled in-vitro heterologous expression system to quantify the activation of CB1 receptors by sixteen cannabis terpenes individually, by tetrahydrocannabinol (THC) alone and by THC-terpenes mixtures. The results demonstrate that all terpenes, when tested individually, activate CB1 receptors, at about 10-50% of the activation by THC alone.

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]]> Table 2 Descriptions of frequently consumed Cannabis flower chemovar index codes https://www.cannabisclinicians.org/2023/03/24/table-2-descriptions-of-frequently-consumed-cannabis-flower-chemovar-index-codes/ Sat, 25 Mar 2023 01:53:21 +0000 https://www.cannabisclinicians.org/?p=28146 Little is known about the frequency with which different combinations of phytochemicals (chemovars) arise in Cannabis flower or whether common chemovars are associated with distinct pharmacodynamics and patient health outcomes. This study created a clinically relevant, user-friendly, scalable chemovar indexing system summarizing primary cannabinoid and terpene contents and tested whether the most frequently consumed chemovars differ in their treatment effectiveness and experienced side effects.

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]]> Comparison of the Cannabinoid and Terpene Profiles in Commercial Cannabis from Natural and Artificial Cultivation https://www.cannabisclinicians.org/2023/03/16/comparison-of-the-cannabinoid-and-terpene-profiles-in-commercial-cannabis-from-natural-and-artificial-cultivation/ Thu, 16 Mar 2023 10:55:17 +0000 https://www.cannabisclinicians.org/?p=28049 Interest in cultivating cannabis for medical and recreational purposes is increasing due to a dramatic shift in cannabis legislation worldwide. Therefore, a comprehensive understanding of the composition of secondary metabolites, cannabinoids, and terpenes grown in different environmental conditions is of primary importance for the medical and recreational use of cannabis. We compared the terpene and cannabinoid profiles using gas/liquid chromatography and mass spectrometry for commercial cannabis from genetically identical plants grown indoors using artificial light and artificially grown media or outdoors grown in living soil and natural sunlight. By analyzing the cannabinoids, we found significant variations in the metabolomic profile of cannabis for the different environments.

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]]> Evaluation of the anti-inflammatory effects of selected cannabinoids and terpenes from Cannabis Sativa L employing human primary leukocytes https://www.cannabisclinicians.org/2022/10/22/evaluation-of-the-anti-inflammatory-effects-of-selected-cannabinoids-and-terpenes-from-cannabis-sativa-l-employing-human-primary-leukocytes/ Sat, 22 Oct 2022 17:43:43 +0000 https://www.cannabisclinicians.org/?p=26972 Cannabis sativa L. is a medicinal plant with a long history. Phyto-cannabinoids are a class of compounds from C. sativa L. with varieties of structures. Endocannabinoids exist in the human body. This article provides an overview of natural cannabinoids (phyto-cannabinoids and endocannabinoids) with an emphasis on their pharmacology activities.

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]]> Analgesic Potential of Terpenes Derived from Cannabis sativa https://www.cannabisclinicians.org/2021/10/27/analgesic-potential-of-terpenes-derived-from-cannabis-sativa/ Thu, 28 Oct 2021 00:02:07 +0000 https://www.cannabisclinicians.org/?p=24883 Decades of research have improved our knowledge of cannabis polypharmacy and contributing phytochemicals, including terpenes. Reform of the legal status for cannabis possession and increased availability (medicinal and recreational) have resulted in cannabis use to combat the increasing prevalence of pain and may help to address the opioid crisis. Better understanding of the pharmacological effects of cannabis and its active components, including terpenes, may assist in identifying new therapeutic approaches and optimizing the use of cannabis and/or terpenes as analgesic agents.

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]]> Therapeutic Applications of Terpenes on Inflammatory Diseases https://www.cannabisclinicians.org/2021/09/15/therapeutic-applications-of-terpenes-on-inflammatory-diseases/ Wed, 15 Sep 2021 14:37:24 +0000 https://www.cannabisclinicians.org/?p=24201 In this context, terpenes are a highly diverse family of natural products which are synthesized by plants. This family have approximately 55,000 members with different chemical structures, presenting potential practical applications (Prakash, 2017; Serrano Vega et al., 2018). For this reason, it has been reported that terpenoids could ameliorate various symptoms caused by inflammation, inhibiting various steps of inflammatory processes. However, due to their low solubility and high instability, some alternatives, such as nanotechnology, have been explored.

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]]> Phytochemical characterization and biological properties of two standardized extracts from a non-psychotropic Cannabis sativa L. cannabidiol (CBD)-chemotype https://www.cannabisclinicians.org/2021/07/05/phytochemical-characterization-and-biological-properties-of-two-standardized-extracts-from-a-non-psychotropic-cannabis-sativa-l-cannabidiol-cbd-chemotype/ Mon, 05 Jul 2021 21:12:07 +0000 https://www.cannabisclinicians.org/?p=23607 The aim of study was to evaluate and compare the phytochemical profile, the antioxidant and antimicrobial properties of two standardized extracts from non-psychotropic (Δ9-tetrahydrocannabinol ≤0.2%) Cannabis sativa L. var. fibrante rich in cannabidiol (CBD). The two extracts, namely Cannabis Fibrante Hexane Extract 1 (CFHE1) and Cannabis Fibrante Hexane Extract 2 (CFHE2), were obtained by extraction with acidified hexane from dried flowering tops as such and after hydrodistillation of the essential oil, respectively.

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]]> Cannabinoid and Terpenoid Doses are Associated with Adult ADHD Status of Medical Cannabis Patients https://www.cannabisclinicians.org/2020/08/31/cannabinoid-and-terpenoid-doses-are-associated-with-adult-adhd-status-of-medical-cannabis-patients/ Mon, 31 Aug 2020 15:50:02 +0000 https://www.cannabisclinicians.org/?p=19432 Authors: Jeffrey Y. Hergenrather, Joshua Aviram, Yelena Vysotski, Salvatore Campisi-Pinto, Gil M. Lewitus, David Meiri Published in Rambam Maimonides Medical Journal January 2020 Abstract Objective The aim of this cross-sectional questionnaire-based study...

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]]> Terpenes/Terpenoids in Cannabis: Are They Important? https://www.cannabisclinicians.org/2020/08/24/terpenes-terpenoids-in-cannabis-are-they-important/ Mon, 24 Aug 2020 15:42:22 +0000 https://www.cannabisclinicians.org/?p=19325 Authors: Hanuš LO. · Hod Y. Published in Karger  August 2020 Abstract Cannabis sativa plant has not only cannabinoids as crucial compounds but also the other compounds that play important role...

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