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Terpenoids From Cannabis Do Not Mediate an Entourage Effect by Acting at Cannabinoid Receptors

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Authors: David B. Finlay, Kathleen J. Sircombe, Mhairi Nimick, Callum Jones, Michelle Glass
Frontiers in Pharmacology, 25 March 2020
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The entourage effect was a proposed explanation for biological observations that endocannabinoid ligand activities can be modified by other lipids released from cells at the same time. An increasing volume of anecdotal reports and interest in the plant have provoked research i…

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Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects.

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Authors: Ethan B. Russo
British Journal of Pharmacology, August 2011
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Tetrahydrocannabinol (THC) has been the primary focus of cannabis research since 1964, when Raphael Mechoulam isolated and synthesized it. More recently, the synergistic contributions of cannabidiol to cannabis pharmacology and analgesia have been scientifically demonstrated…

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