Cell Death – Society of Cannabis Clinicians https://www.cannabisclinicians.org Educating Healthcare Professionals about the Medical Use of Cannabis Wed, 18 Oct 2023 11:22:50 +0000 en-US hourly 1 https://wordpress.org/?v=6.2.3 https://www.cannabisclinicians.org/wp-content/uploads/2020/07/cropped-scc-flavicon-32x32.png Cell Death – Society of Cannabis Clinicians https://www.cannabisclinicians.org 32 32 Cell death induction and intracellular vesicle formation in human colorectal cancer cells treated with Δ9 -Tetrahydrocannabinol https://www.cannabisclinicians.org/2023/10/18/cell-death-induction-and-intracellular-vesicle-formation-in-human-colorectal-cancer-cells-treated-with-%ce%b49-tetrahydrocannabinol/ Wed, 18 Oct 2023 11:22:50 +0000 https://www.cannabisclinicians.org/?p=29453 Δ9-Tetrahydrocannabinol (Δ9-THC) is a principal psychoactive extract of Cannabis sativa and has been traditionally used as palliative medicine for neuropathic pain. Cannabidiol (CBD), an extract of hemp species, has recently attracted increased attention as a cancer treatment, but Δ9-THC is also requiring explored pharmacological application. This study evaluated the pharmacological effects of Δ9-THC in two human colorectal cancer cell lines. We inves-tigated whether Δ9-THC treatment induces cell death in human colorectal cancer cells.

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]]> Endocannabinoids Modulate Human Epidermal Keratinocyte Proliferation and Survival via the Sequential Engagement of Cannabinoid Receptor-1 and Transient Receptor Potential Vanilloid-1 https://www.cannabisclinicians.org/2021/04/04/endocannabinoids-modulate-human-epidermal-keratinocyte-proliferation-and-survival-via-the-sequential-engagement-of-cannabinoid-receptor-1-and-transient-receptor-potential-vanilloid-1-2/ Mon, 05 Apr 2021 02:48:08 +0000 https://www.cannabisclinicians.org/?p=22369 We have recently shown that lipid mediators of the emerging endocannabinoid system (ECS) are key players of growth control of the human pilosebaceous unit. In this study, we asked whether the prototypic endocannabinoid anandamide (N-arachidonoylethanolamine, AEA) has a role in growth and survival of epidermal keratinocytes (KCs).

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]]> Cannabidiol: Assessing preclinical safety in ovarian and endometrial carcinoma cell lines https://www.cannabisclinicians.org/2020/06/12/cbd-safety-ovarian-endometrial-carcinoma-cell-lines/ Fri, 12 Jun 2020 16:54:30 +0000 https://www.cannabisclinicians.org/?p=18491 Authors: Shannon Rush, Arvinder K Kapur, Manish S. Patankar, Lisa Marie Barroilhet Published in Journal of Clinical Oncology May 2020   Abstract Background: Cancer patients use cannabidiol (CBD) for chemotherapy...

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