Sleep – Society of Cannabis Clinicians https://www.cannabisclinicians.org Educating Healthcare Professionals about the Medical Use of Cannabis Mon, 16 Oct 2023 12:00:00 +0000 en-US hourly 1 https://wordpress.org/?v=6.2.3 https://www.cannabisclinicians.org/wp-content/uploads/2020/07/cropped-scc-flavicon-32x32.png Sleep – Society of Cannabis Clinicians https://www.cannabisclinicians.org 32 32 A Double-Blind, Randomized, Placebo-Controlled Study of the Safety and Effects of CBN With and Without CBD on Sleep Quality https://www.cannabisclinicians.org/2023/10/16/a-double-blind-randomized-placebo-controlled-study-of-the-safety-and-effects-of-cbn-with-and-without-cbd-on-sleep-quality/ Mon, 16 Oct 2023 12:00:00 +0000 https://www.cannabisclinicians.org/?p=29444 The present study sought to determine the effects of cannabinol (CBN) alone and in combination with cannabidiol (CBD) on sleep quality. This was a double-blind, randomized, placebo-controlled study conducted between May and November 2022. Participants were randomized to receive either (a) placebo, (b) 20 mg CBN, (c) 20 mg CBN + 10 mg CBD, (d) 20 mg CBN + 20 mg CBD, or (e) 20 mg CBN + 100 mg CBD for seven consecutive nights. Participants were 18–55 years of age who self-rated sleep quality as “very poor” or “poor.” The primary endpoint was sleep quality, while secondary endpoints included sleep onset latency, number of awakenings, wake after sleep onset (WASO), overall sleep disturbance, and daytime fatigue

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]]> Cannabinoids: Emerging sleep modulator https://www.cannabisclinicians.org/2023/07/09/cannabinoids-emerging-sleep-modulator/ Sun, 09 Jul 2023 19:59:17 +0000 https://www.cannabisclinicians.org/?p=28906 Sleep is an essential biological phase of our daily life cycle and is necessary for maintaining homeostasis, alertness, metabolism, cognition, and other key functions across the animal kingdom. Dysfunctional sleep leads to deleterious effects on health, mood, and cognition, including memory deficits and an increased risk of diabetes, stroke, and neurological disorders. Sleep is regulated by several brain neuronal circuits, neuromodulators, and neurotransmitters, where cannabinoids have been increasingly found to play a part in its modulation. Cannabinoids, a group of lipid metabolites, are regulatory molecules that bind mainly to cannabinoid receptors (CB1 and CB2). Much evidence supports the role of cannabinoid receptors in the modulation of sleep, where their alteration exhibits sleep-promoting effects, including an increase in non-rapid-eye movement sleep and a reduction in sleep latency. However, the pharmacological alteration of CB1 receptors is associated with adverse psychotropic effects, which are not exhibited in CB2 receptor alteration. Hence, selective alteration of CB2 receptors is also of clinical importance, where it could potentially be used in treating sleep disorders. Thus, it is crucial to understand the neurobiological basis of cannabinoids in sleep physiology. In this review article, the alteration of the endocannabinoid system by various cannabinoids and their respective effects on the sleep-wake cycle are discussed based on recent findings. The mechanisms of the cannabinoid receptors on sleep and wakefulness are also explored for their clinical implications and potential therapeutic use on sleep disorders.

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]]> The Safety and Effectiveness of Commercially Available Cannabidiol Products for Health and Well-Being: A Randomized, Multi-Arm, Open-Label Waitlist-Controlled Trial https://www.cannabisclinicians.org/2022/12/09/the-safety-and-effectiveness-of-commercially-available-cannabidiol-products-for-health-and-well-being-a-randomized-multi-arm-open-label-waitlist-controlled-trial/ Fri, 09 Dec 2022 23:52:18 +0000 https://www.cannabisclinicians.org/?p=27259 Over the past decade, use of cannabidiol (CBD) to manage common symptoms such as anxiety, sleep disturbance, and pain has expanded rapidly. However, few clinical trials have investigated CBD's safety or efficacy. Furthermore, whether effects vary by characteristics of the product or individual characteristics is largely unknown.

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]]> Survey of Patients Employing Cannabigerol-Predominant Cannabis Preparations: Perceived Medical Effects, Adverse Events, and Withdrawal Symptoms https://www.cannabisclinicians.org/2021/11/17/survey-of-patients-employing-cannabigerol-predominant-cannabis-preparations-perceived-medical-effects-adverse-events-and-withdrawal-symptoms-2/ Thu, 18 Nov 2021 01:12:59 +0000 https://www.cannabisclinicians.org/?p=25188 Analysis of over 100 Cannabis samples quantified for terpene and cannabinoid content and genotyped for over 100,000 single nucleotide polymorphisms indicated that Sativa- and Indica-labelled samples were genetically indistinct on a genome-wide scale. Instead, we found that Cannabis labelling was associated with variation in a small number of terpenes whose concentrations are controlled by genetic variation at tandem arrays of terpene synthase genes.

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]]> Survey of Patients Employing Cannabigerol-Predominant Cannabis Preparations: Perceived Medical Effects, Adverse Events, and Withdrawal Symptoms https://www.cannabisclinicians.org/2021/11/10/survey-of-patients-employing-cannabigerol-predominant-cannabis-preparations-perceived-medical-effects-adverse-events-and-withdrawal-symptoms/ Thu, 11 Nov 2021 01:10:36 +0000 https://www.cannabisclinicians.org/?p=25126 Cannabigerol (CBG), and its precursor before decarboxylation, cannabigerolic acid is sometimes labeled the “mother of all cannabinoids.” The purpose of the present study was to investigate reasons for use and self-reported therapeutic effects in CBG-predominant cannabis users. Usage patterns and adverse effects, including withdrawal symptoms were also explored.

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]]> The Effect of Medical Cannabis on Pain Level and Quality of Sleep among Rheumatology Clinic Outpatients https://www.cannabisclinicians.org/2021/10/20/the-effect-of-medical-cannabis-on-pain-level-and-quality-of-sleep-among-rheumatology-clinic-outpatients/ Wed, 20 Oct 2021 19:19:38 +0000 https://www.cannabisclinicians.org/?p=24781 Medical cannabis (MC) is becoming increasingly popular for the treatment of chronic pain conditions. In this study, we evaluated the effect of MC treatment on pain level and quality of sleep of patients with different medical conditions at the rheumatology clinic.

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]]> Cannabinol and Sleep: Separating Fact from Fiction https://www.cannabisclinicians.org/2021/09/15/cannabinol-and-sleep-separating-fact-from-fiction/ Wed, 15 Sep 2021 14:47:30 +0000 https://www.cannabisclinicians.org/?p=24320 In recent years, marketers of cannabis (i.e., marijuana) products have claimed that cannabinol (CBN) has unique sleep-promoting effects. Despite a plausible mechanism, it is possible that such claims are merely rooted in cannabis lore. The aim of this narrative review was to answer the question: “Is there sufficient clinical evidence to support claims that CBN has sleep-promoting effects?”

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]]> Evaluation of the effects of CBD hemp extract on opioid use and quality of life indicators in chronic pain patients: a prospective cohort study https://www.cannabisclinicians.org/2020/08/12/evaluation-of-the-effects-of-cbd-hemp-extract-on-opioid-use-and-quality-of-life-indicators-in-chronic-pain-patients-a-prospective-cohort-study/ Thu, 13 Aug 2020 02:03:42 +0000 https://www.cannabisclinicians.org/?p=19187 Author: Alex Capano, Richard Weaver & Elisa Burkman Published in Postgraduate Medicine   November 2019 Abstract Context: Chronic pain is highly prevalent in most of the industrialized nations around the world....

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]]> Intraocular pressure, ocular toxicity and neurotoxicity after administration of cannabinol or cannabigerol https://www.cannabisclinicians.org/2020/07/29/intraocular-pressure-ocular-toxicity-and-neurotoxicity-after-administration-of-cannabinol-or-cannabigerol/ Wed, 29 Jul 2020 20:59:12 +0000 https://www.cannabisclinicians.org/?p=19007 Author: Brenda K.Colasanti, Charles R. Craig, R. David Allara Published in Science Direct September 1984 Abstract Cannabinol or cannabigerol was administered to cats topically in doses of 250, 500 and...

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]]> Cannabis (medical marijuana) treatment for motor and non-motor symptoms of Parkinson disease: an open-label observational study. https://www.cannabisclinicians.org/2014/03/30/cannabis-medical-marijuana-treatment-for-motor-and-non-motor-symptoms-of-parkinson-disease-an-open-label-observational-study/ Sun, 30 Mar 2014 18:19:49 +0000 https://www.cannabisclinicians.org/?p=15603 Authors: Itay Lotan, Therese Treves, Yaniv Roditi, Ruth Djaldetti
Clinical Neuropharmacology, March-April 2014
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OBJECTIVE: The use of cannabis as a therapeutic agent for various medical conditions has been well documented. However, clinical trials in patients with Parkinson disease (PD) have yielded conflicting results. The aim of the present open-label observational study was to assess...

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