mastocytosis – Society of Cannabis Clinicians https://www.cannabisclinicians.org Educating Healthcare Professionals about the Medical Use of Cannabis Sat, 18 Feb 2023 20:13:36 +0000 en-US hourly 1 https://wordpress.org/?v=6.2.3 https://www.cannabisclinicians.org/wp-content/uploads/2020/07/cropped-scc-flavicon-32x32.png mastocytosis – Society of Cannabis Clinicians https://www.cannabisclinicians.org 32 32 The Effectiveness and Safety of Pharmaceutical-Grade Cannabidiol in the Treatment of Mastocytosis-Associated Pain: A Pilot Study https://www.cannabisclinicians.org/2023/02/18/the-effectiveness-and-safety-of-pharmaceutical-grade-cannabidiol-in-the-treatment-of-mastocytosis-associated-pain-a-pilot-study/ Sat, 18 Feb 2023 20:09:11 +0000 https://www.cannabisclinicians.org/?p=27786 Mastocytosis patients often experience a number of symptoms, including mastocytosis-associated pain that is difficult to manage due to resistance to usual antalgic treatments and/or the patient’s poor tolerance. Mastocytosis patients display significantly higher levels of indoleamine-2,3-dioxygenase-1 (IDO1) activity, leading to hyperactivation of the N-methyl-D-aspartate receptor. As cannabidiol (CBD) is known to inhibit IDO1′s enzymatic activity, we hypothesized that pharmaceutical-grade CBD is an effective treatment for mastocytosis-associated pain. Patients with non-advanced mastocytosis and refractory pain were eligible for inclusion in this observational pilot study.

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