Pain – Society of Cannabis Clinicians https://www.cannabisclinicians.org Educating Healthcare Professionals about the Medical Use of Cannabis Mon, 02 Oct 2023 21:41:37 +0000 en-US hourly 1 https://wordpress.org/?v=6.2.3 https://www.cannabisclinicians.org/wp-content/uploads/2020/07/cropped-scc-flavicon-32x32.png Pain – Society of Cannabis Clinicians https://www.cannabisclinicians.org 32 32 Cannabinoid modulations of pain and stress related circuits https://www.cannabisclinicians.org/2023/10/02/cannabinoid-modulations-of-pain-and-stress-related-circuits/ Mon, 02 Oct 2023 21:41:37 +0000 https://www.cannabisclinicians.org/?p=29344 In the past decade, significant advancements have been made in understanding the brain regions and neuronal circuits regulating neurological behaviors. The endocannabinoid (eCB) system, which is ubiquitously distributed in the brain and extensively involved in synaptic modulation, has been believed to play potential roles in neuronal circuit processes and related disorders. Although eCB-based pharmacological studies have made some clinical achievements, they still often encounter conflicting reports or undesired effects due to global manipulation of manifold brain regions and neuronal circuits, which impede the therapeutic application of eCB-based medications. In this review, we are devoted to discussing the versatile forms of eCB-mediated synaptic plasticity and dissecting currently well-studied specific cannabinoid circuits involved in behavioral domains which are closely linked to the organism’s survival and life quality, such as pain perception and stress-related emotion disorders. By gaining new insights into selective cannabinoid control in circuits, we can potentially mitigate the drawbacks of traditional pharmacology and facilitate the development of precision medicine with novel therapeutic strategies and drug discoveries.

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]]> A single-center real-life study on the use of medical cannabis in patients with dystonia https://www.cannabisclinicians.org/2023/07/29/a-single-center-real-life-study-on-the-use-of-medical-cannabis-in-patients-with-dystonia/ Sat, 29 Jul 2023 17:21:31 +0000 https://www.cannabisclinicians.org/?p=28989 While cannabis-based medicine is being commonly used in patients with movement disorders, there is a scarcity of publications regarding the effect of cannabis on dystonia. We aimed to describe medical cannabis use in patients with dystonia and related pain. We employed a structured interview to obtain data on the cannabis treatment regimen, perception of effectiveness and side effect profile. Eligible participants were patients diagnosed with dystonia from the movement disorders unit at the Tel-Aviv Medical Center who had used licensed medical cannabis between January 2019 and January 2021.

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]]> Cannabis use in cancer patients: acute and sustained associations with pain, cognition, and quality of life https://www.cannabisclinicians.org/2023/05/05/cannabis-use-in-cancer-patients-acute-and-sustained-associations-with-pain-cognition-and-quality-of-life/ Sat, 06 May 2023 01:12:52 +0000 https://www.cannabisclinicians.org/?p=28524 Given the myriad of negative sequalae associated with cancer and its treatment, the palliative use of cannabis by cancer patients is increasingly of special interest. This research sought to explore associations of acute and sustained use of legal market edible cannabis products on pain, cognition, and quality of life in a group of cancer patients. In this observational study, cancer patients completed a baseline appointment, a two-week ad libitum cannabis use period, and an acute administration appointment that included assessments before cannabis use, one-hour post-use, and two-hour post-use. Participants completed self-report questionnaires related to the primary outcomes and the Stroop task as a measure of objective cognitive function.

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]]> A Retrospective Medical Record Review of Adults with Non-Cancer Diagnoses Prescribed Medicinal Cannabis https://www.cannabisclinicians.org/2023/03/18/a-retrospective-medical-record-review-of-adults-with-non-cancer-diagnoses-prescribed-medicinal-cannabis-2/ Sat, 18 Mar 2023 14:00:49 +0000 https://www.cannabisclinicians.org/?p=28089 Research describing patients using medicinal cannabis and its effectiveness is lacking. We aimed to describe adults with non-cancer diagnoses who are prescribed medicinal cannabis via a retrospective medical record review and assess its effectiveness and safety. From 157 Australian records, most were female (63.7%; mean age 63.0 years). Most patients had neurological (58.0%) or musculoskeletal (24.8%) conditions. Medicinal cannabis was perceived beneficial by 53.5% of patients.

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]]> The Effectiveness and Safety of Pharmaceutical-Grade Cannabidiol in the Treatment of Mastocytosis-Associated Pain: A Pilot Study https://www.cannabisclinicians.org/2023/02/18/the-effectiveness-and-safety-of-pharmaceutical-grade-cannabidiol-in-the-treatment-of-mastocytosis-associated-pain-a-pilot-study/ Sat, 18 Feb 2023 20:09:11 +0000 https://www.cannabisclinicians.org/?p=27786 Mastocytosis patients often experience a number of symptoms, including mastocytosis-associated pain that is difficult to manage due to resistance to usual antalgic treatments and/or the patient’s poor tolerance. Mastocytosis patients display significantly higher levels of indoleamine-2,3-dioxygenase-1 (IDO1) activity, leading to hyperactivation of the N-methyl-D-aspartate receptor. As cannabidiol (CBD) is known to inhibit IDO1′s enzymatic activity, we hypothesized that pharmaceutical-grade CBD is an effective treatment for mastocytosis-associated pain. Patients with non-advanced mastocytosis and refractory pain were eligible for inclusion in this observational pilot study.

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]]> A Retrospective Medical Record Review of Adults with Non-Cancer Diagnoses Prescribed Medicinal Cannabis https://www.cannabisclinicians.org/2023/02/18/a-retrospective-medical-record-review-of-adults-with-non-cancer-diagnoses-prescribed-medicinal-cannabis/ Sat, 18 Feb 2023 16:32:47 +0000 https://www.cannabisclinicians.org/?p=27760 Research describing patients using medicinal cannabis and its effectiveness is lacking. We aimed to describe adults with non-cancer diagnoses who are prescribed medicinal cannabis via a retrospective medical record review and assess its effectiveness and safety. From 157 Australian records, most were female (63.7%; mean age 63.0 years). Most patients had neurological (58.0%) or musculoskeletal (24.8%) conditions. Medicinal cannabis was perceived beneficial by 53.5% of patients.

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]]> The Safety and Effectiveness of Commercially Available Cannabidiol Products for Health and Well-Being: A Randomized, Multi-Arm, Open-Label Waitlist-Controlled Trial https://www.cannabisclinicians.org/2022/12/09/the-safety-and-effectiveness-of-commercially-available-cannabidiol-products-for-health-and-well-being-a-randomized-multi-arm-open-label-waitlist-controlled-trial/ Fri, 09 Dec 2022 23:52:18 +0000 https://www.cannabisclinicians.org/?p=27259 Over the past decade, use of cannabidiol (CBD) to manage common symptoms such as anxiety, sleep disturbance, and pain has expanded rapidly. However, few clinical trials have investigated CBD's safety or efficacy. Furthermore, whether effects vary by characteristics of the product or individual characteristics is largely unknown.

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]]> A Randomized Controlled Trial of Topical Cannabidiol for the Treatment of Thumb Basal Joint Arthritis https://www.cannabisclinicians.org/2022/09/03/a-randomized-controlled-trial-of-topical-cannabidiol-for-the-treatment-of-thumb-basal-joint-arthritis/ Sat, 03 Sep 2022 18:56:11 +0000 https://www.cannabisclinicians.org/?p=26722 Since the passage of the Agricultural Improvement Act of 2018, hand surgeons have increasingly encountered patients seeking counseling on over-the-counter, topical cannabidiol (CBD) for the treatment of pain. To this end, we designed a human clinical trial to investigate the therapeutic potential of CBD for the treatment of pain associated with thumb basal joint arthritis.

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]]> Cannabis, Cannabinoids and Cannabis-Based Medicines in Cancer Care https://www.cannabisclinicians.org/2022/08/11/cannabis-cannabinoids-and-cannabis-based-medicines-in-cancer-care/ Thu, 11 Aug 2022 13:48:05 +0000 https://www.cannabisclinicians.org/?p=26632 Cannabis sativa has long been known to affect numerous biological activities. Although plant extracts, purified cannabinoids, or synthetic cannabinoid analogs have shown therapeutic potential in pain, inflammation, seizure disorders, appetite stimulation, muscle spasticity, and treatment of nausea/vomiting, the underlying mechanisms of action remain ill-defined.

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]]> Tetrahydrocannabinol and cannabidiol medicines for chronic pain and mental health conditions https://www.cannabisclinicians.org/2022/08/11/tetrahydrocannabinol-and-cannabidiol-medicines-for-chronic-pain-and-mental-health-conditions/ Thu, 11 Aug 2022 10:59:03 +0000 https://www.cannabisclinicians.org/?p=26623 Combination tetrahydrocannabinol (THC)/cannabidiol (CBD) medicines or CBD-only medicines are prospective treatments for chronic pain, stress, anxiety, depression, and insomnia. THC and CBD increase signaling from cannabinoid receptors, which reduces synaptic transmission in parts of the central and peripheral nervous systems and reduces the secretion of inflammatory factors from immune and glial cells.

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