Hyperalgesia – Society of Cannabis Clinicians https://www.cannabisclinicians.org Educating Healthcare Professionals about the Medical Use of Cannabis Sun, 06 Nov 2022 00:08:08 +0000 en-US hourly 1 https://wordpress.org/?v=6.2.3 https://www.cannabisclinicians.org/wp-content/uploads/2020/07/cropped-scc-flavicon-32x32.png Hyperalgesia – Society of Cannabis Clinicians https://www.cannabisclinicians.org 32 32 Role of the endocannabinoid system in the pathophysiology of endometriosis and therapeutic implications https://www.cannabisclinicians.org/2022/11/05/role-of-the-endocannabinoid-system-in-the-pathophysiology-of-endometriosis-and-therapeutic-implications/ Sat, 05 Nov 2022 23:54:22 +0000 https://www.cannabisclinicians.org/?p=27119 Endometriosis patients experience debilitating chronic pain, and the first-line treatment is ineffective at managing symptoms. Although surgical removal of the lesions provides temporary relief, more than 50% of the patients experience disease recurrence. Despite being a leading cause of hysterectomy, endometriosis lacks satisfactory treatments and a cure. Another challenge is the poor understanding of disease pathophysiology which adds to the delays in diagnosis and overall compromised quality of life. Endometriosis patients are in dire need of an effective therapeutic strategy that is both economical and effective in managing symptoms, while fertility is unaffected. Endocannabinoids and phytocannabinoids possess anti-inflammatory, anti-nociceptive, and anti-proliferative properties that may prove beneficial for endometriosis management, given that inflammation, vascularization, and pain are hallmark features of endometriosis.

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]]> Cannabis in painful HIV-associated sensory neuropathy: a randomized placebo-controlled trial https://www.cannabisclinicians.org/2021/06/17/cannabis-in-painful-hiv-associated-sensory-neuropathy-a-randomized-placebo-controlled-trial/ Thu, 17 Jun 2021 19:09:18 +0000 https://www.cannabisclinicians.org/?p=23339 Aim: To determine the effect of smoked cannabis on the neuropathic pain of HIV-associated sensory neuropathy and an experimental pain model.

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]]> Irritable Bowel Syndrome: Manipulating the Endocannabinoid System as First-Line Treatment https://www.cannabisclinicians.org/2020/09/10/irritable-bowel-syndrome-manipulating-the-endocannabinoid-system-as-first-line-treatment/ Thu, 10 Sep 2020 18:32:32 +0000 https://www.cannabisclinicians.org/?p=19539 Authors: Viola Brugnatelli, Fabio Turco, Ulderico Freo and Gastone Zanette Published in Frontiers in Neuroscience April 2020 Introduction Irritable Bowel Syndrome (IBS) is a functional disorder characterized by abdominal pain,...

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]]> Effect of cannabidiolic acid and ∆9-tetrahydrocannabinol on carrageenan-induced hyperalgesia and edema in a rodent model of inflammatory pain. https://www.cannabisclinicians.org/2018/11/01/effect-of-cannabidiolic-acid-and-%e2%88%869-tetrahydrocannabinol-on-carrageenan-induced-hyperalgesia-and-edema-in-a-rodent-model-of-inflammatory-pain/ Thu, 01 Nov 2018 15:23:24 +0000 https://www.cannabisclinicians.org/?p=15267 Authors: Erin M. Rock, Cheryl L. Limebeer, Linda A. Parker
Psychopharmacology, November 2018
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RATIONALE: Cannabidiol (CBD), a non-intoxicating component of cannabis, or the psychoactive Δ9-tetrahydrocannabiol (THC), shows anti-hyperalgesia and anti-inflammatory properties. OBJECTIVES: The present study evaluates the anti-inflammatory and anti-hyperalgesia effects of CB...

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]]> Cannabidiol prevents the development of cold and mechanical allodynia in paclitaxel-treated female C57Bl6 mice. https://www.cannabisclinicians.org/2011/10/01/cannabidiol-prevents-the-development-of-cold-and-mechanical-allodynia-in-paclitaxel-treated-female-c57bl6-mice/ Sat, 01 Oct 2011 19:12:19 +0000 https://www.cannabisclinicians.org/?p=15646 Authors: Sara Ward, Michael Ramirez, Harshini Neelakantan, Ellen Walker
Anesthesia and Analgesia, October 2011
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The taxane chemotherapeutic paclitaxel frequently produces peripheral neuropathy in humans. Rodent models to investigate mechanisms and treatments are largely restricted to male rats, whereas female mouse studies are lacking. We characterized a range of paclitaxel doses on col...

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]]> Endocannabinoid involvement in endometriosis. https://www.cannabisclinicians.org/2010/12/01/endocannabinoid-involvement-in-endometriosis/ Wed, 01 Dec 2010 14:34:46 +0000 https://www.cannabisclinicians.org/?p=15757 Authors: Natalia Dmitrieva, Hiroshi Nagabukuro, David Resuehr, Guohua Zhang, Stacy McAllister, et al
Pain, December 2010
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Endometriosis is a disease common in women that is defined by abnormal extrauteral growths of uterine endometrial tissue and associated with severe pain. Partly because how the abnormal growths become associated with pain is poorly understood, the pain is difficult to alleviat...

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]]> Pain measurements and side effect profile of the novel cannabinoid ajulemic acid. https://www.cannabisclinicians.org/2005/06/01/pain-measurements-and-side-effect-profile-of-the-novel-cannabinoid-ajulemic-acid/ Wed, 01 Jun 2005 15:41:42 +0000 http://cannabisclinicians.org/?p=5683 Authors: Kahlid Salim, Udo Schneider, Sumner Burstein, Ludwig Hoy, Matthias Karst
Neuropharmacology, June 2005
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Preclinical findings on ajulemic acid (AJA) showed analgesic and anti-allodynic effects without psychoactive properties making it an appealing substance for the treatment of pain. A recently published randomized double-blind crossover clinical trial described the pain-reducing...

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