cannabigerol – Society of Cannabis Clinicians https://www.cannabisclinicians.org Educating Healthcare Professionals about the Medical Use of Cannabis Sat, 23 Sep 2023 14:03:20 +0000 en-US hourly 1 https://wordpress.org/?v=6.2.3 https://www.cannabisclinicians.org/wp-content/uploads/2020/07/cropped-scc-flavicon-32x32.png cannabigerol – Society of Cannabis Clinicians https://www.cannabisclinicians.org 32 32 Toxicity of Cannabigerol: Examination of Long-Term Toxicity and Lifespan in Caenorhabditis elegans and 14-Day Study in Sprague Dawley Rats https://www.cannabisclinicians.org/2023/09/23/toxicity-of-cannabigerol-examination-of-long-term-toxicity-and-lifespan-in-caenorhabditis-elegans-and-14-day-study-in-sprague-dawley-rats/ Sat, 23 Sep 2023 14:03:20 +0000 https://www.cannabisclinicians.org/?p=29266 Cannabigerol (CBG) is becoming widely available despite little being known about its potential toxicity or long-term effects. The present investigation involved two distinct studies. The first study explored acute and long-term effects of CBG on toxicity, lifespan, and aging in adult Caenorhabditis elegans (C. elegans). Animals were treated with CBG (0.075 lM–3.75 mM) to determine acute toxicity, mortality, and motility. Acute heat- induced stress survival (thermotolerance; 37°C for 4 h) following CBG administration (0.075–3.75 mM) was measured. Long-term toxicity of lifelong CBG administration (7.5, 75, or 375 lM CBG) was determined through changes in motility and lifespan duration. In the second study, healthy, adult, Sprague Dawley rats received 0, 35, 70, or 140 mg/kg-bw/day CBG (n = 5 per sex per group) daily for 14 days via oral gavage. Signs of gross toxicity and changes in behavior, body weight, food consumption, and serum chemistry were monitored. Liver, kidney, and adrenal gland weights were recorded, and histopathology of select tissues was examined.

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]]> Therapeutic Potential of Phytocannabinoid Cannabigerol for Multiple Sclerosis: Modulation of Microglial Activation In Vitro and In Vivo https://www.cannabisclinicians.org/2023/02/22/therapeutic-potential-of-phytocannabinoid-cannabigerol-for-multiple-sclerosis-modulation-of-microglial-activation-in-vitro-and-in-vivo/ Thu, 23 Feb 2023 00:08:20 +0000 https://www.cannabisclinicians.org/?p=27810 Multiple sclerosis (MS) is a widespread chronic neuroinflammatory and neurodegenerative disease. Microglia play a crucial role in the pathogenesis of MS via the release of cytokines and reactive oxygen species, e.g., nitric oxide. Research involving the role of phytocannabinoids in neuroinflammation is currently receiving much attention. Cannabigerol is a main phytocannabinoid, which has attracted significant pharmacological interest due to its non-psychotropic nature. In this research, we studied the effects of cannabigerol on microglial inflammation in vitro, followed by an in vivo study. Cannabigerol attenuated the microglial production of nitric oxide in BV2 microglia and primary glial cells; concomitant treatment of the cells with cannabigerol and telmisartan (a neuroprotective angiotensin receptor blocker) decreased nitric oxide production additively. Inducible nitric oxide synthase (iNOS) expression was also reduced by cannabigerol.

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]]> Cannabidiol and Cannabigerol Exert Antimicrobial Activity without Compromising Skin Microbiota https://www.cannabisclinicians.org/2023/02/19/cannabidiol-and-cannabigerol-exert-antimicrobial-activity-without-compromising-skin-microbiota/ Sun, 19 Feb 2023 14:46:43 +0000 https://www.cannabisclinicians.org/?p=27795 Cannabidiol (CBD) and cannabigerol (CBG) are two pharmacologically active phytocannabinoids of Cannabis sativa L. Their antimicrobial activity needs further elucidation, particularly for CBG, as reports on this cannabinoid are scarce. We investigated CBD and CBG’s antimicrobial potential, including their ability to inhibit the formation and cause the removal of biofilms. Our results demonstrate that both molecules present activity against planktonic bacteria and biofilms, with both cannabinoids removing mature biofilms at concentrations below the determined minimum inhibitory concentrations. We report for the first time minimum inhibitory and lethal concentrations for Pseudomonas aeruginosa and Escherichia coli (ranging from 400 to 3180 µM), as well as the ability of cannabinoids to inhibit Staphylococci adhesion to keratinocytes, with CBG demonstrating higher activity than CBD.

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]]> An Examination of the Anti-Cancer Properties of Plant Cannabinoids in Preclinical Models of Mesothelioma https://www.cannabisclinicians.org/2022/08/26/an-examination-of-the-anti-cancer-properties-of-plant-cannabinoids-in-preclinical-models-of-mesothelioma/ Fri, 26 Aug 2022 22:40:14 +0000 https://www.cannabisclinicians.org/?p=26676 Mesothelioma is an aggressive cancer with limited treatment options and a poor prognosis. Phytocannabinoids possess anti-tumour and palliative properties in multiple cancers, however their effects in mesothelioma are unknown. We investigated the anti-cancer effects and potential mechanisms of action for several phytocannabinoids in mesothelioma cell lines.

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]]> Major Phytocannabinoids and Their Related Compounds: Should We Only Search for Drugs That Act on Cannabinoid Receptors? https://www.cannabisclinicians.org/2021/11/29/major-phytocannabinoids-and-their-related-compounds-should-we-only-search-for-drugs-that-act-on-cannabinoid-receptors/ Mon, 29 Nov 2021 23:35:04 +0000 https://www.cannabisclinicians.org/?p=25302 The most important discoveries in pharmacology, such as certain classes of analgesics or chemotherapeutics, started from natural extracts which have been found to have effects in traditional medicine. Cannabis, traditionally used in Asia for the treatment of pain, nausea, spasms, sleep, depression, and low appetite, is still a good candidate for the development of new compounds. If initially all attention was directed to the endocannabinoid system, recent studies suggest that many of the clinically proven effects are based on an intrinsic chain of mechanisms that do not necessarily involve only cannabinoid receptors.

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]]> In vitro and in vivo pharmacological activity of minor cannabinoids isolated from Cannabis sativa https://www.cannabisclinicians.org/2020/11/30/in-vitro-and-in-vivo-pharmacological-activity-of-minor-cannabinoids-isolated-from-cannabis-sativa/ Mon, 30 Nov 2020 16:51:19 +0000 https://www.cannabisclinicians.org/?p=20771 Authors: Ayat Zagzoog, Kawthar A. Mohamed, Hye Ji J. Kim, Eunhyun D. Kim, Connor S. Frank, Tallan Black, Pramodkumar D. Jadhav, Larry A. Holbrook & Robert B. Laprairie Published in...

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]]> Efficacy of combined therapy with fish oil and phytocannabinoids in murine intestinal inflammation https://www.cannabisclinicians.org/2020/11/02/efficacy-of-combined-therapy-with-fish-oil-and-phytocannabinoids-in-murine-intestinal-inflammation/ Mon, 02 Nov 2020 16:07:16 +0000 https://www.cannabisclinicians.org/?p=20431 Authors: Ester Pagano, Fabio A. Iannotti, Fabiana Piscitelli, Barbara Romano, Giuseppe Lucariello, Tommaso Venneri, Vincenzo Di Marzo, Angelo A. Izzo, Francesca Borrelli Published in Phytotherapy Research September 2020 Abstract Summary...

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]]> Delegitimizing Cannabis Because of Its Recreational Use is the Real Lie https://www.cannabisclinicians.org/2020/10/09/delegitimizing-cannabis-because-of-its-recreational-use-is-the-real-lie/ Fri, 09 Oct 2020 08:18:41 +0000 https://www.cannabisclinicians.org/?p=19895 Sherry Yafai, MD encourages the need for healthcare professionals to shift their perspective on cannabis in her column for Emergency Medicine News. "Delegitimizing medications based simply on their potential for recreational use or abuse is a dangerous and uninformed approach for physicians."

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]]> Intraocular pressure, ocular toxicity and neurotoxicity after administration of cannabinol or cannabigerol https://www.cannabisclinicians.org/2020/07/29/intraocular-pressure-ocular-toxicity-and-neurotoxicity-after-administration-of-cannabinol-or-cannabigerol/ Wed, 29 Jul 2020 20:59:12 +0000 https://www.cannabisclinicians.org/?p=19007 Author: Brenda K.Colasanti, Charles R. Craig, R. David Allara Published in Science Direct September 1984 Abstract Cannabinol or cannabigerol was administered to cats topically in doses of 250, 500 and...

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]]> Cannabinoids infused mouthwash products are as effective as chlorhexidine on inhibition of total-culturable bacterial content in dental plaque samples https://www.cannabisclinicians.org/2020/07/25/cannabinoid-infused-mouthwash-products-are-as-effective-as-chlorhexidine-on-inhibition-of-total-culturable-bacterial-content-in-dental-plaque-samples/ Sat, 25 Jul 2020 13:36:40 +0000 https://www.cannabisclinicians.org/?p=18933 Author: Kumar Vasudevan & Veronica Stahl Published in The Journal of Cannabis Research June 2020 Abstract Background  Dental plaque is a global health problem affecting people of various age groups. Cannabinoids...

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